How BerGen Bio are developing treatments for aggressive, drug resistant cancers.




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Video title: How BerGen Bio are developing treatments for aggressive, drug resistant cancers.
Released on: September 03, 2014. © PTV
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In This Episode:
    Cancer is the leading cause of death in people under the age of 65.
  • Summary
  • Transcript
  • Participants
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Cancer is the leading cause of death in people under the age of 65. While the detection and treatment of primary cancer has improved significantly, frequently these cancers recur as secondary, metastatic tumors and tend to be very aggressive and drug resistance, causing most fatalities. Effective prognostic and therapeutic options for such invasive drug resistant cancers remain a significant unmet medical need. Understanding how secondary tumors become invasive (metastatic) and resist current treatments is a major health issue. BerGenBio is a leader in understanding the biological drivers of aggressive drug resistant cancers and is committed to discovering and developing novel drugs for treating these cancers. Using our platform technology, CellSelect™, we have identified and validated several novel targets that mediate EMT, the cellular process that makes cancers metastatic and drug resistant. We have secured this understanding with intellectual property rights and are developing biomarkers and first-in-class drugs to inhibit these targets and will progress these drug candidates into human clinical trials. During the AngloNordic Conferencve in London,Richard Godfrey updates Fintan Walton on how things are progressing intheir clinical trials.
Cancer is the leading cause of death in people under the age of 65. While the detection and treatment of primary cancer has improved significantly, frequently these cancers recur as secondary, metastatic tumors and tend to be very aggressive and drug resistance, causing most fatalities. Effective prognostic and therapeutic options for such invasive drug resistant cancers remain a significant unmet medical need. Understanding how secondary tumors become invasive (metastatic) and resist current treatments is a major health issue. BerGenBio is a leader in understanding the biological drivers of aggressive drug resistant cancers and is committed to discovering and developing novel drugs for treating these cancers. Using our platform technology, CellSelect™, we have identified and validated several novel targets that mediate EMT, the cellular process that makes cancers metastatic and drug resistant. We have secured this understanding with intellectual property rights and are developing biomarkers and first-in-class drugs to inhibit these targets and will progress these drug candidates into human clinical trials. During the AngloNordic Conferencve in London,Richard Godfrey updates Fintan Walton on how things are progressing intheir clinical trials.
Richard Godfrey
Bergen Bio
BerGenBio
BerGenBio AS is a privately-held biotech company focused on developing novel therapeutics for metastatic and drug resistant cancers by targeting the epithelial to mesenchymal transition (EMT) process in cancer cells. The EMT is a process in which epithelial cells undergo multiple phenotypic changes that enhance their migratory capacity, invasiveness and resistance to apoptosis. The Company’s lead program BGB324 which is due to enter Phase I clinical trials in Q1/2013, is a novel, orally bioavailable inhibitor of Axl kinase, a key target in the EMT process and associated with drug resistance and poor prognosis in a a number of cancer types . BerGenBio is discovering novel targets in the EMT area through its proprietary CellSelect technology, which is a powerful target discovery and validation tool providing greater biological insight to the role and function of targets and illustrates their potential for therapeutic benefit through regulated dose response therapeutic-mimetic studies of target inhibition and translational preclinical modeling. The technology is also used in identification and validation of pharmacodynamic markers, a key part of the company’s clinical development strategy for its programs. Based on this technology, the Company is building a pipeline of novel validated targets in the EMT arena for different cancer indications. The Company was spun out of University of Bergen in Norway, by Professor Jim Lorens, a thought leader in the field of EMT and cancer stem cells and Dr David Micklem, who developed the CellSelect target discovery and validation technology. The Company has raised significant funds from a syndicate of Norwegian investors. With its headquarters in Bergen Norway, BerGenBio has established a fully integrated research and development infrastructure that discovers and validates novel drug targets of EMT and rapidly develops therapeutics against these. With a profound understanding of cancer biology and unique target validation data the company is able to establish leadership status in the EMT and cancer stem cell area providing first-in-class therapeutics for hard to treat cancers.